Correlation of mutational status with morphologic diagnosis of myeloid neoplasms

Myeloid neoplasms constitute heterogeneous malignancies of the hematopoietic stem cell or progenitor cell. Nearly 30 genes are recurrently mutated in myeloid neoplasms: these include genes involved in proliferative signaling, RNA splicing, the cohesin complex, transcription factors, epigenetic modifiers, and metabolic regulators. One aspect that remains to be explored is which particular gene mutations occur in specific subtypes of myeloid neoplasms, such as acute myeloid leukemia, myelodysplastic neoplasms, myelofibrosis, and chronic myelomonocytic leukemia. In this project, students will perform correlative analysis (using the EMR) to match mutational status with disease diagnosis from the UMass Leukemia Registry. Dr. Patel will provide the raw data (including the information on mutations and the diagnoses for approximately 800 patients with myeloid neoplasms) for the correlative analysis to be performed