Process Development and Optimization of NHP Antibodies and Their Conjugates

By zammitti, 1 February, 2025

The Nonhuman Primate Reagent Resource (NHPRR) has played a crucial role in advancing non-human primate (NHP) studies by developing, characterizing, manufacturing, and distributing antibodies that target specific immune pathways. These immune-modulating and cell-depleting antibodies facilitate groundbreaking research in areas such as HIV/AIDS, transplantation, and autoimmune diseases.

This project will concentrate on antibody conjugates, which are an emerging class of functionalized antibodies with enhanced therapeutic potential. The student will gain hands-on experience in both upstream and downstream processing, including cell culture techniques, chromatography, filtration, and analytical characterization techniques such as ELISA, SDS-PAGE, and spectrophotometry. Additionally, the trainee will develop conjugation strategies to ensure the stability and functionality of antibody-therapeutic conjugates.

Through this experience, the trainee will acquire essential skills in biomanufacturing and biopharmaceutical development, with a particular emphasis on improving the efficacy and translational potential of monoclonal antibodies and their conjugates for transformative medical therapies.

Start Date
End Date
Contact Last Name
Magnani
Contact First Name
Dr. Diogo
Contact E-mail
diogo.magnani@umassmed.edu
Project Type
Translational Research
Location
Massachusetts Biomedical Initiatives (MBI), 17 Briden St, Worcester, MA 01605
Department
Medicine
Roles and Responsibilities
Lab Experiments
Stipend
Yes