The Nonhuman Primate Reagent Resource (NHPRR) has played a crucial role in advancing non-human primate (NHP) studies by developing, characterizing, manufacturing, and distributing antibodies that target specific immune pathways. These immune-modulating and cell-depleting antibodies facilitate groundbreaking research in areas such as HIV/AIDS, transplantation, and autoimmune diseases.
This project will concentrate on antibody conjugates, which are an emerging class of functionalized antibodies with enhanced therapeutic potential. The student will gain hands-on experience in both upstream and downstream processing, including cell culture techniques, chromatography, filtration, and analytical characterization techniques such as ELISA, SDS-PAGE, and spectrophotometry. Additionally, the trainee will develop conjugation strategies to ensure the stability and functionality of antibody-therapeutic conjugates.
Through this experience, the trainee will acquire essential skills in biomanufacturing and biopharmaceutical development, with a particular emphasis on improving the efficacy and translational potential of monoclonal antibodies and their conjugates for transformative medical therapies.